Lower gastrointestinal bleeding secondary to Chronic Nonspecific Ulcerative Colitis: A clinical case

Main Article Content

Dr. Miguel Ángel Martínez Cárdenas https://orcid.org/0009-0007-2890-0755
Dra. Miriam Noemí García Vázquez https://orcid.org/0009-0009-3696-6521
Dra. Martha Elena López González https://orcid.org/0009-0001-3629-6814
Dra. Alma Patricia González https://orcid.org/0000-0002-3401-7519
Dr. Carlos Paque Bautista https://orcid.org/0000-0002-2658-0491
Dr. Arturo Maximiliano Reyes Sosa https://orcid.org/0000-0002-1233-4580
Dr. Mario Murguía Pérez https://orcid.org/0000-0003-4260-389X
Dr. Luis de Jesús Prieto Utrera https://orcid.org/0009-0006-4113-1404
Dr. Arturo Reyes Hernández https://orcid.org/0000-0002-7426-8240
Gloria Patricia Sosa-Bustamante https://orcid.org/0000-0002-8460-4965

Keywords

Colitis, Ulcerative, Hemorrhage, Gastrointestinal Tract, Adolescent, Colonoscopy

Abstract

Background: Gastrointestinal bleeding (GIB) has a low incidence in pediatrics. It could be of the upper or lower track, the first one being the most common. Etiology varies according to the age group. Chronic nonspecific ulcerative colitis (UC) is heterogeneous in nature, with a varying severity among patients. The purpose of the present manuscript is to exhibit the unusual case in pediatrics of an adolescent with a lower tract GIB due to UC.


Clinical case: A 16-year-old female was brought to the pediatric emergency department for a lower tract GIB. Ten days prior receiving medical attention, she presented with hematochezia, Bristol 3 consistency, straining and a pattern of 5 times a day. She also presented with moderately intense abdominal pain located in the hypogastrium and mid-gastric region, cramp-like, non-irradiating, which partially resolved upon bowel movements. She also presented with fatigue, weakness, and weight loss of approximately 3 kg; no fever. She had no personal history of illness. A colonoscopy was performed, revealing friable, erythematous intestinal mucosa alongside layered bleeding and fibrin plaques in the descending, transverse, and ascending colon. Biopsies were taken from the entire colon and rectum. The diagnosis of UC was confirmed based on clinical, endoscopic, and anatomopathological criteria.


Conclusion: The present case shows how a previously healthy adolescent presented with UC manifested by lower tract GIB, abdominal pain, and wasting syndrome, a rare condition in the pediatric population.

Abstract 24 | PDF (Spanish) Downloads 27

References

1. Amin SK, Antunes C. Lower Gastrointestinal Bleeding. 2023. In: StatPearls. Treasure Island (FL): StatPearls Publishing; 2025.

2. Piccirillo M, Pucinischi V, Mennini M, et al. Gastrointestinal bleeding in children: diagnostic approach. Ital J Pediatr. 2024;50(1):13. doi: 10.1186/s13052-024-01592-2.

3. Barker-Antonio A, Jarquin-Arremilla A, García-Manzano RA, et al. Uso de la enteroscopía intraoperatoria como método diagnóstico en pacientes con sangrado gastrointestinal de origen oscuro. Experiencia inicial. Rev Med Inst Mex Seguro Soc. 2021;59(6):560-567. Disponible en: http://revistamedica.imss.gob.mx/editorial/index.php/revista_medica/article/view/4167/4297

4. Cotter J, Baldaia C, Ferreira M, et al. Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review. World J Gastroenterol. 2020;26(45):7242-7257. doi: 10.3748/wjg.v26.i45.7242.

5. Jovel-Banegas LE, Cadena-León JF, Cázares-Méndez JM, et al. Sangrado del tubo digestivo en pediatría. Diagnóstico y tratamiento. Acta Pediatr Mex. 2013;34:280-287.

6. Kuenzig ME, Fung SG, Marderfeld L, et al. Twenty-first Century Trends in the Global Epidemiology of Pediatric-Onset Inflammatory Bowel Disease: Systematic Review. Gastroenterology. 2022;162(4):1147-1159.e4. doi: 10.1053/j.gastro.2021.12.282.

7. Yamamoto-Furusho JK, Sarmiento-Aguilar A, Toledo-Mauriño JJ, et al. Incidence and prevalence of inflammatory bowel disease in Mexico from a nationwide cohort study in a period of 15 years (2000-2017). Medicine. 2019;98(27):e16291. doi: 10.1097/MD.0000000000016291.

8. Kim DH, Cheon JH. Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies. Immune Netw. 2017;17(1):25-40. doi: 10.4110/in.2017.17.1.25.

9. Nakase H, Uchino M, Shinzaki S, et al. Evidence-based clinical practice guidelines for inflammatory bowel disease 2020. J Gastroenterol. 2021;56(6):489-526. doi: 10.1007/s00535-021-01784-1.

10. Management of Pediatric Ulcerative Colitis, Part 1: Ambulatory Care-An Evidence-based Guideline From European Crohn's and Colitis Organization and European Society of Paediatric Gastroenterology, Hepatology and Nutrition: Erratum. J Pediatr Gastroenterol Nutr. 2020;71(6):794. doi: 10.1097/MPG.0000000000002967.

11. Turner D, Ruemmele FM, Orlanski-Meyer E, et al. Management of Paediatric Ulcerative Colitis, Part 2: Acute Severe Colitis-An Evidence-based Consensus Guideline From the European Crohn's and Colitis Organization and the European Society of Paediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr. 2018;67(2):292-310. doi: 10.1097/MPG.0000000000002036.

12. Carman N, Picoraro JA. Advances in Endoscopy for Pediatric Inflammatory Bowel Disease. Gastrointest Endosc Clin N Am. 2023;33(2):447-461. doi: 10.1016/j.giec.2022.10.002.

13. Navalón-Rubio M, Bautista-Casasnovas A. Hemorragia digestiva alta y baja en edad pediátrica. Protoc diagn ter pediatr. 2023;1:65-76.

14. Fuxman C, Sicilia B, Linares ME, et al. GADECCU 2022 Guideline for the treatment of Ulcerative Colitis. Adaptation and updating of the GETECCU 2020 Guideline. Gastroenterol Hepatol. 2023;46 Suppl 1:S1-S56. doi: 10.1016/j.gastrohep.2023.01.009.

15. Nakase H. Acute Severe Ulcerative Colitis: Optimal Strategies for Drug Therapy. Gut Liver. 2023;17(1):49-57. doi: 10.5009/gnl220017.

16. A. Bischoff SC, Escher J, Hébuterne X, et al. Guía ESPEN: Nutrición clínica en la enfermedad inflamatoria intestinal [ESPEN guideline: Clinical nutrition in inflammatory bowel disease]. Nutr Hosp. 2022;39(3):678-703. doi: 10.20960/nh.03857.

17. Zerpa C. Contrasting Psychotherapeutic Treatments in Inflammator Bowel Disease: an Exploratory Review. Rev Costarric Psic. 2024;43(1):5256.

18. Sun Y, Yuan S, Chen X, et al. The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study. Am J Gastroenterol. 2023;118(3):511-522. doi: 10.14309/ajg.0000000000002180.

19. Guan DX, Wu J, Zhang J, et al. [Clinical features and risk factors for early relapse of pediatric ulcerative colitis]. Zhonghua Er Ke Za Zhi. 2022;60(7):660-665. Chinese. doi: 10.3760/cma.j.cn112140-20220401-00271.

20. Puppala ER, Aochenlar SL, Shantanu PA, et al. Perillyl alcohol attenuates chronic restraint stress aggravated dextran sulfate sodium-induced ulcerative colitis by modulating TLR4/NF-κB and JAK2/STAT3 signaling pathways. Phytomedicine. 2022;106:154415. doi: 10.1016/j.phymed.2022.154415.

21. Florou M, Diamantopoulos C, Anastasiadis K, et al. Bilateral Ureteral Obstruction in Children With Ulcerative Colitis and Oliguria: When and Why? Cureus. 2024;16(8):e67031. doi: 10.7759/cureus.67031.

22. Miller M, Patel AS, Pasternak B. Rescue therapy with Upadacitinib in medically refractory pediatric ulcerative colitis. JPGN Rep. 2024;5(2):197-199. doi: 10.1002/jpr3.12067.

23. Zhang T, Pan ZB, Tong WJ, et al. A Case of Ulcerative Colitis Induced by Paraneoplastic Syndrome? J Inflamm Res. 2023;16:3319-3327. doi: 10.2147/JIR.S418733.

24. Fukura S, Takei M, Takeuchi S, et al. A pediatric case of infliximab-resistant ulcerative colitis successfully treated using vedolizumab. J Med Invest. 2023;70(1.2):294-297. doi: 10.2152/jmi.70.294.

25. Cucinotta U, Dipasquale V, Costa S, et al. Vedolizumab-associated pulmonary manifestations in children with ulcerative colitis. J Clin Pharm Ther. 2022;47(2):254-256. doi: 10.1111/jcpt.13494.