Two lymphomas in the same patient: A case report
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Keywords
Lymphatic Diseases, Lymphoma Non-Hodgki, Hodgkin Disease
Abstract
Background: The synchronous association of Hodgkin lymphoma and non-Hodgkin lymphoma in the same patient is very rare.
Case report: A 68 years old male patient who began his disease with cervical and axillary adenomegaly, it was performed an excisional biopsy and a mixed cell-type Hodgkin lymphoma was found. Chemotherapy with partial response was initiated. During the course of the treatment, refractory lesions were observed in skin and muscle. Radiation oncology service decided to make a second biopsy which confirms the presence of a large diffuse B cell non-Hodgkin lymphoma.
Conclusions: This case is an example of how when you have a patient with a typical clinical picture of bad prognosis, the diagnosis should be reconsidered and laboratory studies previously done must be repeated to rule out alternative diagnoses that may change the course of the disease.
References
1. Pérez-Zúñiga JM, Aguilar-Andrade C, Álvarez-Vera JL, Augusto-Pacheco M, Báez-Islas PE, Bates-Martín RA, et al. Generalidades sobre linfomas. Rev Hematol Mex. 2018;19(4):174-88.
2. Labardini-Me?ndez JR, Cervera-Ceballos E, Corrales-Alfaro C, Balbuena-Marti?nez M, Barbosa-Ibarra AA, Espinoza-Zamora JR, et al. Oncoguía. Linfoma de Hodgkin. Cancerologi?a. 2011;6(1):133-8.
3. Bowzyk-AlNaeeb A, Ajithkumar T, Behan S, James-Hodson D. Non-Hodgkin lymphoma. BMJ 2018;362:k3204. doi:10.1136/bmj.k3204
4. Armitage JO, Gascoyne RD, Lunning MA, Cavalli F. Non-Hodgkin lymphoma. Lancet. 2017;390(10091):298-310. doi:10.1016/s0140-6736(16)32407-2
5. Schaapveld M, Aleman BM, van Eggermond AM, Janus CP, Krol AD, van der Maazen RW, et al. Second cancer risk up to 40 years after treatment for Hodgkin's lymphoma. N Engl J Med. 2015;373:2499-511. doi:10.1056/NEJMoa1505949
6. Wang HW, Yang W, Wang L, Lu YL, Lu JY. Composite diffuse large B-cell lymphoma and classical Hodgkin's lymphoma of the stomach:case report and literature review. World J Gastroenterol. 2013;19(37):6304-9. doi:10.3748/wjg.v19.i37.6304
7. Nishioka A, Ureshino H, Ando T, Kizuka H, Kusaba K, Sano H, et al. Three coexisting lymphomas in a single patient:composite lymphoma derived from a common germinal center B-cell precursor and unrelated discordant lymphoma. Int J Hematol. 2018;107(6):703-8. doi:10.1007/s12185-017-2370-6
8. Park J, Eun-Lee J, Kim M, Lim J, Kim Y, Han K, et al. Discordant lymphocyte-depleted classical Hodgkin's and peripheral T-cell lymphoma arising in a patient 11 years after diagnosis of multicentric Castleman's disease. Int J Hematol. 2013;98(1):114-21. doi:10.1007/s12185-013-1358-0
9. Lloveras N, Pleusa E, Mate JL, Batlle M. Linfoma compuesto. Med Clin (Barc). 2003;121(8):316-9.
10. Vicente-Baz D, Ruiz-Borrego M, Medina M, Moreno-Nogueira JA. Linfoma compuesto. Med Clin (Barc). 2003;120(6):236-9.
11. Zhang C, Yi Y, Chen C, Wang J, Liu Z. Discordant lymphoma consisting of mediastinal large B-cell lymphoma and nodular sclerosis Hodgkin lymphoma in the right supraclavicular lymph nodes:a case report. Diagn Pathol Open Access. 2015;10:215. doi:10.1186/s13000-015-0450-6
12. Coyne J, Kealy WF, Hogan F, Murphy C. Discordant lymphoma:a case report. Irish J Med Sci. 1987;156(3):104-5.
13. Cannizzo E, Sohani AR, Ferry JA, Hochberg EP, Kluk MJ, Dorn ME, et al. Carcinoma and multiple lymphomas in one patient:establishing the diagnoses and analyzing risk factors. J Hematopathol. 2009;2:163-70. doi:10.1007/s12308-009-0041-0
14. Shingaki S, Yoshiki Y, Yamamoto K, Ota Y, Suzuki K. Coexistent adrenal diffuse large B cell lymphoma in a patient with Waldenström's macroglobinemia/lymphoplasmacytic lymphoma. Ann Hematol. 2016;95:1723-4. doi:10.1007/s00277-016-2735-6
15. Pérez-Montaña A, Sancho JM, Mate JL, Ribera JM. Asociación temporal de linfoma de Hodgkin y linfoma no hodgkiniano:estudio de 6 pacientes en un solo centro. Med Clin (Barc). 2012;139(15):694-7.
16. Kendric K, Goyal G, Caponetti G. Synchronous Hodgkin lymphoma and diffuse large B cell lymphoma:a rare coexistence. J Hosp Med. 2016;11(Suppl 1):abstr. 605. Disponible en:https://shmabstracts.org/abstract/synchronous-hodgkin-lymphoma-and-diffuse-large-b-cell-lymphoma-a-rare-coexistence/.
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