Solitary fibrous tumor of the prostate mimicking a tumor of the vesicoprostatic junction. Case report

Main Article Content

Huber Díaz-Fuentes https://orcid.org/0000-0001-5622-7245
Juan Carlos Zapot-Martínez https://orcid.org/0009-0008-7409-1263
Norma Alejandra Cabrera-Mora https://orcid.org/0000-0002-1087-134X
Eduardo Ramos-Arceo https://orcid.org/0009-0009-7140-8699
Juana Sonia Tavares-García https://orcid.org/0009-0006-0730-6338

Keywords

Prostate, Solitary Fibrous Tumors, Cystoprostatectomy

Abstract

Abstract


Background: Differentiating among the various neoplasms of the urinary and reproductive system in adult patients is essential for establishing an accurate diagnosis and determining the appropriate therapeutic strategy.


Clinical case: 71-year-old man with a history of Gleason 10 (5+5) prostate adenocarcinoma who developed a suspicious lesion at the vesicoprostatic junction, initially considered a urothelial carcinoma based on cystoscopy findings and immunohistochemistry. Following a multidisciplinary evaluation, a radical cystoprostatectomy with lymphadenectomy was performed, which subsequently revealed a solitary fibrous tumor of the prostate, a rare entity with benign behavior. Immunohistochemical analysis was key to the final diagnosis, differentiating this benign lesion from the initially suspected urothelial origin.


Conclusions: This case underscores the importance of a comprehensive and meticulous approach in the evaluation of atypical prostate lesions, as misdiagnoses can lead to overtreatment. The experience reported here highlights the need to consider solitary fibrous tumors in the differential diagnosis of prostatic stromal tumors.

Abstract 38 | PDF (Spanish) Downloads 112

References

1. Vengjer A, Paiva MM, Moccellin EGP, et al. Solitary fibrous tumor of the prostate: Case report and literature review. Urol Case Rep. 2025;63:103207. doi: 10.1016/j.eucr.2025.103207

2. Liao J, Liu X, DU W, et al. [Laparoscopic radical resection of large (223 g) solitary fibrous tumor of the prostate: a case report]. Nan Fang Yi Ke Da Xue Xue Bao. 2023;43(12):2158-62. [Article in Chinese]. doi: 10.12122/j.issn.1673-4254.2023.12.23

3. Takeuchi Y, Kato D, Nakane K, et al. Solitary Fibrous Tumor of the Prostate: A Case Report and Literature Review. Medicina (Kaunas). 2021;57(11):1152. doi: 10.3390/medicina57111152

4. Matos J, Paparo F, Calcagno T, et al. Solitary Fibrous Tumor of the Prostate. Urology. 2020;141:e43-4. doi: 10.1016/j.urology.2020.04.003

5. Hevia Feliu A, Gómez González B, Muñoz Fernández de Legaria M, et al. Growing solitary fibrous tumor of the prostate during COVID-19 pandemic. Urol Case Rep. 2022;43:102121. doi: 10.1016/j.eucr.2022.102121

6. Peng Y, Jiang Y, Ding S, et al. Solitary fibrous tumors in prostate: a case report with review of the literature. Aging Male. 2022;25(1):219-27. doi: 10.1080/13685538.2022.2110232

7. Eich ML, Furlano K, Hilfenhaus G, et al. Solitary fibrous tumor of the prostate with accompanying low-grade prostate cancer. Urol Case Rep. 2024;57:102879. doi: 10.1016/j.eucr.2024.102879

8. Nishith N, Gupta M, Kaushik N, et al. Solitary Fibrous Tumor of the Prostate: A Diagnostic Challenge: A Case Report. Iran J Pathol. 2020;15(1):41-4. doi: 10.30699/IJP.2019.104669.2069

9. Okubo Y, Nukada S, Shibata Y, et al. Primary solitary fibrous tumour of the prostate: A case report and literature review. Malays J Pathol. 2020;42(3):449-53.

10. McKenney JK. Mesenchymal tumors of the prostate. Modern Pathology. 2018 Jan;31(S1):S133-142. doi: 10.1038/modpathol.2017.155

11. Bakhshwin A, Berry RS, Cox RM, et al. Malignant solitary fibrous tumour of the prostate: four cases emphasising significant histological and immunophenotypical overlap with sarcomatoid carcinoma. Pathology. 2020;52(6):643-8. doi: 10.1016/j.pathol.2020.06.004

12. Xu Y, Li Z, Shi J, et al. Clinicopathological features to distinguish malignant solitary fibrous tumors of the prostate from prostatic stromal tumors. Virchows Arch. 2021;478(4):619-26. doi: 10.1007/s00428-020-02909-2

13. Heger P, Hill A, Charchenko C. CD-34 negative solitary fibrous tumor of the prostate: A case report. Urol Case Rep. 2024;57:102855. doi: 10.1016/j.eucr.2024.102855

14. Ye X, Yu H, Sun B, et al. Malignant solitary fibrous tumor of the seminal vesicle: a case report and review of the literature. BMC Urol. 2025;25(1):119. doi: 10.1186/s12894-025-01815-6

15. Wahlstedt E, Zhou C, Strup S, et al. Locally advanced solitary fibrous tumour of the prostate. BMJ Case Rep. 2023;16(10):e257666. doi: 10.1136/bcr-2023-257666

16. Yang T, Zhu R, Guo Z, et al. Solitary Fibrous Tumor of the Prostate Shown on FAPI PET/CT. Clin Nucl Med. 2023;48(6):530-531. doi: 10.1097/RLU.0000000000004635

17. Ronchi A, La Mantia E, Gigantino V, et al. A rare case of malignant solitary fibrous tumor in prostate with review of the literature. Diagn Pathol. 2017;12(1):50. doi: 10.1186/s13000-017-0640-5

18. Ruan HJ, Huang AH, Cheng S, et al. [Clinicopathologic features of solitary fibrous tumor in urogenital system]. Zhonghua Bing Li Xue Za Zhi. 2016;45(4):248-51. [Article in Chinese]. doi: 10.3760/cma.j.issn.0529-5807.2016.04.007

19. Lobo J, Harik LR, Peyton CC, et al. Solitary fibrous tumours involving the genitourinary tract: a case series in rare locations, highlighting the role of STAT6 immunohistochemistry. Virchows Arch. 2024;484(4):697-702. doi: 10.1007/s00428-023-03694-4

20. Stolzenbach LF, Fankhauser CD, Mattei A, et al. Solitary Fibrous Tumor of the Prostate Treated with Frozen-Section Supported Robot-Assisted Nerve-Sparing Radical Prostatectomy. Urol Int. 2023;107(10-12):977-82. doi: 10.1159/000534088

21. Ahnou D, Belkacem-Nacer A, Boubrit M. Tumeur fibreuse solitaire de la prostate: à propos d’un cas. Pan Afr Med J. 2021;39:285. doi: 10.11604/pamj.2021.39.285.30406