Glycemic control of type 2 diabetes: primary care pre-pandemic versus COVID-19 pandemic
Main Article Content
Keywords
Primary Health Care, COVID-19, Diabetes Mellitus, Type 2
Abstract
Background: Keeping an adequate glycemic control is a major global challenge. Approximately 42% of individuals achieve the recommended HbA1c targets.
Objective: To compare glycemic control in 2 independent cohorts of patients with type 2 diabetes mellitus treated before and during the COVID-19 pandemic in primary care in Mexico City.
Material and methods: Analytical observational study; records of 3598 patients with 2 HbA1c determinations (2562 pre-pandemic and 1036 pandemic) from 213 health units were analyzed. Means, proportions, and t and chi-squared tests were calculated; metabolic control was defined as HbA1c ≤ 8%.
Results: Mean HbA1c was 9.1% in both groups in the first measurement; at the last measurement, it was lower in the pre-pandemic group (8.0% vs. 8.3%; p < 0.001). The percentage of controlled patients increased from 38.5% to 58.5% pre-pandemic and from 37.8% to 54.2% during the pandemic (p = 0.017). Dual oral therapy achieved the greatest increase in control (22.5% pre-pandemic, 28.3% pandemic); isolated insulin therapy and absence of pharmacological treatment were less effective under pandemic conditions.
Conclusions: The pandemic was associated with lower glycemic control; however, regimens with 1 or 2 oral antidiabetic agents retained their effectiveness. Ensuring continuity of care, drug supply, and support for lifestyle measures will be crucial in future crises.
References
1. World Health Organization. Diabetes. Fact sheets. Geneva: WHO; 14 November 2024. Disponible en: https://www.who.int/news-room/fact-sheets/detail/diabetes
2. Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 11th edition. Diabetes Res Clin Pract. 2019;157:107843. doi: 10.1016/j.diabres.2019.107843
3. International Diabetes Federation. IDF Diabetes Atlas 2024. Brussels: International Diabetes Federation; 2024. Disponible en: https://diabetesatlas.org/
4. Parker ED, Lin J, Mahoney T, et al. Economic costs of diabetes in the U.S. in 2022. Diabetes Care. 2024;47(1):26-43. doi: 10.2337/dci23-0085
5. Centro Nacional de Excelencia Tecnológica en Salud. Prevención, diagnóstico, metas de control ambulatorio y referencia oportuna de la diabetes mellitus tipo 2 en el primer nivel de atención: Guía de referencia rápida. México: CENETEC; 2019. Disponible en: https://www.cenetec-difusion.com/CMGPC/GPC-SS-093-19/ER.pdf
6. NORMA Oficial Mexicana NOM-015-SSA2-2010, Para la prevención, tratamiento y control de la diabetes mellitus. México: Diario Oficial de la Federación; 2010. Disponible en: https://www.dof.gob.mx/normasOficiales/4215/salud/salud.htm
7. Basto-Abreu A, Barrientos-Gutiérrez T, Rojas-Martínez R, et al. Prevalencia de diabetes y descontrol glucémico en México: Resultados de la Ensanut 2016. Salud Publica Mex. 2020;62(1):50-9. doi: 10.21149/10752
8. Calixto AAS, Franco LJ, La Banca Barber RO, et al. Glycemic outcomes of people with diabetes mellitus in Brazilian primary health care. Int J Diabetes Dev Ctries. 2024;44(1):91-98. doi: 10.1007/s13410-023-01203-6
9. Elgart JF, Silvestrini C, Prestes M, et al. Drug treatment of type 2 diabetes: Its cost is significantly associated with HbA1c levels. International Journal of Clinical Practice. 2019;73(4):e13336. doi: 10.1111/IJCP.13336
10. Rossaneis MA, de Andrade SM, Gvozd R, et al. Fatores associados ao controle glicêmico de pessoas com diabetes mellitus. Cien Saude Colet. 2019;24(3):997-1005. doi: 10.1590/1413-81232018243.02022017
11. Instituto Nacional de Estadística y Geografía. Estadísticas a propósito del Día Mundial de la Diabetes (14 de noviembre). Datos nacionales. Comunicado de prensa núm. 645/21. México: INEGI; 2022.
12. Montoya A, Gallardo-Rincón H, Silva-Tinoco R, et al. Type 2 diabetes epidemic in Mexico: Burden of disease 1990-2021 analysis and implications for public policies. Gac Med Mex. 2024;159(6):488-500. doi: 10.24875/gmm.m24000835
13. Shamah-Levy T, Romero-Martínez M, Barrientos-Gutiérrez T, et al. Encuesta Nacional de Salud y Nutrición 2021 sobre COVID-19: Resultados nacionales. Cuernavaca: Instituto Nacional de Salud Pública; 2021.
14. Instituto Mexicano del Seguro Social. Guía de práctica clínica GPC diabetes mellitus tipo 2 en el primer nivel de atención evidencias y recomendaciones catálogo maestro de guías de práctica clínica: gpc-IMSS-718-18. México: IMSS; 2018. Disponible en: http://imss.gob.mx/profesionales-salud/gpc
15. Charan J, Biswas T. How to calculate sample size for different study designs in medical research? Indian J Psychol Med. 2013;35(2):121-6. doi: 10.4103/0253-7176.116232
16. Mares-Gutiérrez Y, Gallardo-Hernández A, Lazcano-Ponce E, et al. Descontrol glucémico: desafío de salud pública en prepandemia y pandemia. Salud Publica Mex. 2023;65(3):227-35. doi: 10.21149/14425
17. American Diabetes Association Professional Practice Committee. Glycemic targets: Standards of medical care in diabetes—2022. Diabetes Care. 2022;45(Suppl 1):S83-96. doi: 10.2337/dc22-s006
18. Department of Veterans Affairs & Department of Defense. VA/DoD clinical practice guideline for the management of type 2 diabetes mellitus. 2023. Disponible en: https://www.healthquality.va.gov/guidelines/CD/diabetes/VADoD-Diabetes-CPG_Final_508.pdf
19. Gerstein HC, Miller ME, Genuth S, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358(24):2545-59. doi: 10.1056/nejmoa0802743
20. Qaseem A, Wilt TJ, Kansagara D, et al. Hemoglobin A1c targets for glycemic control with pharmacologic therapy for nonpregnant adults with type 2 diabetes mellitus: a guidance statement update from the American College of Physicians. Ann Intern Med. 2018;168(8):569-76. doi: 10.7326/m17-0939
21. Gajate-Martín J, Villoch Salgueiro L, Fernández Manchado E, et al. Impacto de la pandemia de COVID-19 en el control glucémico de pacientes diabéticos tipo 2 en un centro de salud urbano. Med Gen Fam. 2023;12(4):149-53. doi: 10.24038/mgyf.2023.037
22. Biamonte E, Pegoraro F, Carrone F, et al. Weight change and glycemic control in type 2 diabetes patients during COVID-19 pandemic: The lockdown effect. Endocrine. 2021;72(3):604-10. doi: 10.1007/s12020-021-02739-5
23. Patel SY, McCoy RG, Barnett ML, et al. Diabetes care and glycemic control during the COVID-19 pandemic in the United States. JAMA Intern Med. 2021;181(10):1412-4. doi: 10.1001/jamainternmed.2021.3047
24. Vilanova CDDA, Sporquio NG, Barcelos LdQ, et al. Glycemic Control in People With Type 2 Diabetes Mellitus Seen in Primary Care During the Covid-19 Pandemic. Research Square; 2023. doi: 10.21203/rs.3.rs-2996049/v1.
25. Morales RDP, González-Cantú A, Garza-Silva A, et al. Effect of the SARS-CoV-2 pandemic on metabolic control in patients with type 2 diabetes: A 5-year cohort follow-up managed by a dynamic multidisciplinary team in Northeastern Mexico. Diabetol Metab Syndr. 2024;16:94. doi: 10.1186/s13098-024-01318-8
26. Formiga F, Franch-Nadal J, Rodríguez L, et al. Inadequate glycaemic control and therapeutic management of adults over 65 years old with type 2 diabetes mellitus in Spain. J Nutr Health Aging. 2017;21(10):1365-70. doi: 10.1007/s12603-017-0869-4
27. Hernández Arroyo MJ, Díaz Madero A, Enríquez Gutiérrez E, et al. Control glucémico en pacientes diabéticos tipo 2 de edad avanzada: Intervención para evitar riesgos. Med Fam SEMERGEN. 2020;46(7):457-63. doi: 10.1016/j.semerg.2020.01.006
28. Laiteerapong N, Ham SA, Gao Y, et al. The Legacy Effect in Type 2 Diabetes: Impact of Early Glycemic Control on Future Complications (The Diabetes & Aging Study). Diabetes Care. 2019;42(3):416-26. doi: 10.2337/dc17-1144
29. American Diabetes Association Professional Practice Committee. 4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Care in Diabetes—2025. Diabetes Care. 2025;48(Suppl 1):S59-85. doi: 10.2337/dc25-S004
